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A switch towards Th2 during serological rebound in children with congenital toxoplasmosis.


Clin Exp Immunol. 1999 Sep;117(3):524-8. Unique Identifier : AIDSLINE

Serological rebounds occur frequently in patients with congenital toxoplasmosis, but remain poorly understood. A link between Th1 and Th2 cytokines and the pathophysiology of infectious diseases has been reported. Production of interferon-gamma (IFN-gamma) and IL-4 in supernatants of whole blood after in vitro specific Toxoplasma gondii stimulation and serum-specific IgE levels were studied in 31 congenitally infected children. IFN-gamma was produced at higher levels by lymphocytes from children with stable congenital toxoplasmosis (n = 18) than from children showing serological rebound (n = 13) (P < 0.04). Conversely, supernatants from children with serological rebound showed higher levels of IL-4 than those from children with stable congenital toxoplasmosis (P < 0.03). The polarized Th2 response was confirmed by a greater (IL-4:IFN-gamma) x 100 ratio (P < 0.0001) and production of T. gondii-specific IgE in six out of 13 children showing serological rebound. These results suggest a role of Th2 cytokines in destabilization of congenital toxoplasmosis and perhaps in local reactivation of the parasite.

JOURNAL ARTICLE Adult Animal Child CD4 Lymphocyte Count Follow-Up Studies Human IgE/BLOOD/IMMUNOLOGY Immunophenotyping Interferon Type II/SECRETION Interleukin-4/SECRETION Mice Receptors, Interleukin-2/BIOSYNTHESIS Th1 Cells/*IMMUNOLOGY Th2 Cells/*IMMUNOLOGY Toxoplasma/*IMMUNOLOGY Toxoplasmosis, Congenital/*IMMUNOLOGY Tumor Cells, Cultured


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