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NLM AIDSLINE

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts.




 

Immunity. 1999 Aug;11(2):183-90. Unique Identifier : AIDSLINE

In the absence of thymic emigration, the peripheral T cell pool is maintained by division of mature lymphocytes. We have examined the molecular interactions required for peripheral CD8+ T cell expansion in lymphopenic mice without conventional antigenic stimulation. Expansion of CD8+ T cells in lymphopenic hosts was found to be peptide specific. An antagonist peptide known to serve as a ligand for positive selection of these T cells promoted expansion; however, a control peptide that binds the same class I molecule did not. Surprisingly, the cells undergoing proliferation in lymphopenic hosts did not mature to cytotoxic effectors and displayed a partially activated surface phenotype. These data suggest that division of T cells in the periphery of lymphopenic hosts requires specific recognition of self-peptide/MHC complexes, similar to the signal for thymocyte maturation.

JOURNAL ARTICLE Animal ABC Transporters/PHYSIOLOGY Cytotoxicity, Immunologic CD8-Positive T-Lymphocytes/*IMMUNOLOGY Histocompatibility Antigens Class I/PHYSIOLOGY Immunophenotyping Ligands *Lymphocyte Transformation Lymphopenia/*IMMUNOLOGY Mice Mice, Inbred C57BL Receptors, Antigen, T-Cell/*PHYSIOLOGY Receptors, Interleukin-2/ANALYSIS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.



 




Information in this article was accurate in November 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.