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Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts.


Immunity. 1999 Aug;11(2):183-90. Unique Identifier : AIDSLINE

In the absence of thymic emigration, the peripheral T cell pool is maintained by division of mature lymphocytes. We have examined the molecular interactions required for peripheral CD8+ T cell expansion in lymphopenic mice without conventional antigenic stimulation. Expansion of CD8+ T cells in lymphopenic hosts was found to be peptide specific. An antagonist peptide known to serve as a ligand for positive selection of these T cells promoted expansion; however, a control peptide that binds the same class I molecule did not. Surprisingly, the cells undergoing proliferation in lymphopenic hosts did not mature to cytotoxic effectors and displayed a partially activated surface phenotype. These data suggest that division of T cells in the periphery of lymphopenic hosts requires specific recognition of self-peptide/MHC complexes, similar to the signal for thymocyte maturation.

JOURNAL ARTICLE Animal ABC Transporters/PHYSIOLOGY Cytotoxicity, Immunologic CD8-Positive T-Lymphocytes/*IMMUNOLOGY Histocompatibility Antigens Class I/PHYSIOLOGY Immunophenotyping Ligands *Lymphocyte Transformation Lymphopenia/*IMMUNOLOGY Mice Mice, Inbred C57BL Receptors, Antigen, T-Cell/*PHYSIOLOGY Receptors, Interleukin-2/ANALYSIS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.


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