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Hold everything! Holding policies for protecting plasma supplies.


Math Biosci. 1999 Sep;160(2):159-73. Unique Identifier : AIDSLINE

In spite of advances in testing technologies for detecting infections such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), occasionally blood or plasma is collected that is potentially infectious, but is not detected as such by existing screening tests. We consider the effect of a holding policy for further reducing the number of potentially infectious units that are released for fractionation. The policy dictates a holding period during which all donated units are stored. If a donor tests positive for the infection in question at a subsequent donation, then all of that donor's units currently in storage are discarded. Otherwise, donated units are released at the end of the holding period. In the case of a single disease, we determine optimal holding periods as well as policies that are as effective as the best screening tests currently available.

JOURNAL ARTICLE Blood Banks/*STANDARDS *Blood Donors Blood-Borne Pathogens Cost-Benefit Analysis Human *Models, Biological *Models, Organizational Organization and Administration *Plasma Support, U.S. Gov't, P.H.S.


Information in this article was accurate in November 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.