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Molecular epidemiology of human T-cell leukemia virus type I (HTLV-1) Brazil: the predominant HTLV-1s in South America differ from HTLV-ls of Japan and Africa, as well as those of Japanese immigrants and their relatives in Brazil.


Virology. 1999 Aug 15;261(1):59-69. Unique Identifier : AIDSLINE

To better understand the origin of human T-cell leukemia virus type l (HTLV-l) in South America, we conducted a phylogenetic study on 27 new HTLV-ls in Brazil. These were obtained from Brazilians of various ethnic origins, such as Japanese immigrants, whites, blacks and mulattos. We amplified and sequenced proviral DNAs of a part of the long terminal repeats. Phylogenetic trees revealed that all but 6 of the new isolates were not only similar to each other but also similar to HTLV-ls of other South American countries, including those from Amerindians. However, the isolates differed from the HTLV-ls of Africa and Japan. The other six isolates were from Japanese immigrants and were phylogenetically almost identical to HTLV-ls in Japan but different from the majority of South American HTLV-ls, including the other new Brazilian HTLV-ls. These findings indicate that the recent introduction of HTLV-1 from Japan is limited to Japanese immigrants. In addition, the results do not support the prevailing hypothesis that HTLV-ls in South America have spread from Amerindians, some of whom are likely to have possessed this human retrovirus from the beginning of their settlement in South America.

JOURNAL ARTICLE Adult Africa Aged Aged, 80 and over Base Sequence Brazil/EPIDEMIOLOGY Emigration and Immigration Epidemiology, Molecular Ethnic Groups Female Human HTLV-I/*GENETICS/ISOLATION & PURIF HTLV-I Infections/*EPIDEMIOLOGY/*VIROLOGY Japan/ETHNOLOGY Male Middle Age Molecular Sequence Data *Phylogeny Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Sequence Analysis, DNA Support, Non-U.S. Gov't Terminal Repeat Sequences/GENETICS


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