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Effect of immune activation induced by Cryptosporidium parvum whole antigen on in vitro human immunodeficiency virus type 1 infection.


J Infect Dis. 1999 Aug;180(2):559-63. Unique Identifier : AIDSLINE

Previous epidemiologic investigations have suggested that persons with AIDS who are infected with Cryptosporidium parvum have a shorter survival time than those with other opportunistic infections. In this study, the effect of immune activation by a crude Cryptosporidium whole antigen on human immunodeficiency virus type 1 (HIV-1) infection was evaluated. Peripheral blood mononuclear cells from healthy persons without HIV-1 infection had increased proliferative and cytokine (interleukin-4, interferon-gamma, and tumor necrosis factor [TNF]-alpha) responses to stimulation with the crude Cryptosporidium whole antigen. This stimulation increased HIV-1 p24 antigen production in in vitro infection by>30-fold. A similar increase in p24 production was also seen when stimulation was done after cells were infected with HIV-1. Neutralization of TNF-alpha reduced Cryptosporidium antigen-induced p24 production by >50%. Results of this study suggest that Cryptosporidium-induced immune activation may be a cofactor in regulating HIV-1 production.

JOURNAL ARTICLE Animal Antigens, Protozoan/*IMMUNOLOGY Cells, Cultured Cryptosporidium parvum/*IMMUNOLOGY Cytokines/BIOSYNTHESIS Human HIV Core Protein p24/*BIOSYNTHESIS HIV-1/*PHYSIOLOGY Leukocytes, Mononuclear/*IMMUNOLOGY/*VIROLOGY Lymphocyte Transformation Tumor Necrosis Factor/BIOSYNTHESIS


Information in this article was accurate in November 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.