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Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization.


J Infect Dis. 1999 Aug;180(2):534-7. Unique Identifier : AIDSLINE

The pathophysiology of oropharyngeal candidiasis in patients infected with human immunodeficiency virus (HIV) type 1 is poorly understood. Association between oropharyngeal yeast carriage and various clinical factors in HIV-1-infected patients was studied in 83 patients with no clinical evidence of thrush and no recent antifungal use. Of the clinical factors measured, the only correlate of yeast colonization was with plasma HIV-1 RNA levels (P=.001), whereas the correlation with CD4 cell count was poor (P=.36). By multivariable regression modeling, plasma HIV-1 RNA was the only parameter that correlated with the extent of colonization with Candida infection (P=.003). These data indicate that the presence and amount of asymptomatic oropharyngeal yeast carriage in persons with HIV-1 infection is more significantly correlated with plasma HIV-1 RNA levels than with CD4 cell count. Further studies on the effect of HIV-1 on oropharyngeal yeast colonization, infection, and local immunity are warranted.

JOURNAL ARTICLE Adult Aged AIDS-Related Opportunistic Infections/*MICROBIOLOGY/VIROLOGY Candida/*ISOLATION & PURIF Candidiasis, Oral/*MICROBIOLOGY/PHYSIOPATHOLOGY Carrier State/MICROBIOLOGY Colony Count, Microbial Cross-Sectional Studies CD4 Lymphocyte Count Female Human HIV-1/*PHYSIOLOGY Male Middle Age Oropharynx/MICROBIOLOGY RNA, Viral/*BLOOD Support, U.S. Gov't, Non-P.H.S. Viremia/VIROLOGY


Information in this article was accurate in November 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.