J Infect Dis. 1999 Aug;180(2):534-7. Unique Identifier : AIDSLINE
The pathophysiology of oropharyngeal candidiasis in patients infected
with human immunodeficiency virus (HIV) type 1 is poorly understood.
Association between oropharyngeal yeast carriage and various clinical
factors in HIV-1-infected patients was studied in 83 patients with no
clinical evidence of thrush and no recent antifungal use. Of the
clinical factors measured, the only correlate of yeast colonization was
with plasma HIV-1 RNA levels (P=.001), whereas the correlation with CD4
cell count was poor (P=.36). By multivariable regression modeling,
plasma HIV-1 RNA was the only parameter that correlated with the extent
of colonization with Candida infection (P=.003). These data indicate
that the presence and amount of asymptomatic oropharyngeal yeast
carriage in persons with HIV-1 infection is more significantly
correlated with plasma HIV-1 RNA levels than with CD4 cell count.
Further studies on the effect of HIV-1 on oropharyngeal yeast
colonization, infection, and local immunity are warranted.
JOURNAL ARTICLE Adult Aged AIDS-Related Opportunistic
Infections/*MICROBIOLOGY/VIROLOGY Candida/*ISOLATION & PURIF
Candidiasis, Oral/*MICROBIOLOGY/PHYSIOPATHOLOGY Carrier
State/MICROBIOLOGY Colony Count, Microbial Cross-Sectional Studies
CD4 Lymphocyte Count Female Human HIV-1/*PHYSIOLOGY Male Middle Age
Oropharynx/MICROBIOLOGY RNA, Viral/*BLOOD Support, U.S. Gov't,