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NLM AIDSLINE

Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men.




 

J Infect Dis. 1999 Aug;180(2):299-309. Unique Identifier : AIDSLINE

Polymorphic products of genes in the HLA region contributing to variability in the course of human immunodeficiency virus type 1 (HIV-1) infection were identified by screening 375 Caucasian seroconverters who were aggregated from 3 cohorts. AIDS-free time was related to numerous (15) class I alleles, alone or in conjunction with transporter protein variants, to homozygosity at the A or B locus, and to alleles of two class II haplotypes. A prognostic scoring algorithm derived from the 3 cohorts captured multiple HLA contributions to protection or to risk (relative hazard=0.57-60 per unit increase in score, all P<<.001). The impact of HLA was strong and appeared independent of the effects of chemokine receptor/ligand polymorphisms and antiretroviral treatment. The algorithm also predicted divergent rates of CD4+ cell decline in 2 other groups, totaling 227 seropositive persons (P=.06 - <.001). Confirmation of these relationships should encourage investigation of HIV-1 antigen processing and presentation mediated by polymorphisms in the HLA region.

JOURNAL ARTICLE MULTICENTER STUDY Adult Algorithms Antigen Presentation Carrier Proteins/*GENETICS/METABOLISM Cohort Studies CD4 Lymphocyte Count Disease Progression Genes, MHC Class I Genes, MHC Class II Histocompatibility Antigens Class I/*GENETICS/METABOLISM Histocompatibility Antigens Class II/*GENETICS/METABOLISM *Homosexuality, Male Homozygote Human HIV Infections/IMMUNOLOGY/*PHYSIOPATHOLOGY HIV Seropositivity *HIV-1 Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.



 




Information in this article was accurate in November 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.