Prescrire Int. 1999 Feb;8(39):22. Unique Identifier : AIDSLINE
(1) Nephrolithiasis is found in 4-13% of patients treated with
indinavir, an HIV protease inhibitor. Most of these stones are composed
of indinavir. (2) Outcome is often favourable, with simple passage of
the stone, but endoscopic or surgical treatment is sometimes required.
(3) Crystalluria seems to be more frequent, but is often asymptomatic.
(4) Prevention is based on fluid intake of at least 1.5 litres a day.
Indinavir withdrawal may be necessary.
JOURNAL ARTICLE HIV Protease Inhibitors/*ADVERSE EFFECTS Human
Indinavir/*ADVERSE EFFECTS *Kidney
Calculi/CHEMISTRY/EPIDEMIOLOGY/PREVENTION & CONTROL/ THERAPY Treatment