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Interleukin-2 restores natural killer activity inhibited by sera from HIV+ hemophilic patients.




 

Medicina (B Aires). 1999;59(2):162-6. Unique Identifier : AIDSLINE

Natural killer (NK) activity is impaired in patients with positive serology for the human immunodeficiency virus (HIV). We previously found an inhibitory effect of sera from hemophilic (He) HIV+ patients on normal NK activity. In the present study, we have further characterized this effect by studying its reversibility, temperature and time incubation dependence. Since interleukin 2 (IL-2) is able to enhance NK levels, we analyzed the capacity of this lymphokine to reverse the effect of He HIV+ sera. We found that when IL-2 activation of NK activity occurred simultaneously or after HIV+ serum-treatment, a significant restoration of NK function was observed. In contrast, preincubation with IL-2 did not affect the inhibitory effect exerted by HIV+ sera.

JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS Cytotoxicity, Immunologic Hemophilia A/*BLOOD/COMPLICATIONS Human HIV Infections/*BLOOD/COMPLICATIONS Interleukin-2/*PHARMACOLOGY Killer Cells, Natural/*DRUG EFFECTS/IMMUNOLOGY Support, Non-U.S. Gov't Time Factors



 




Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.