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Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.




 

Antiviral Res. 1999 Jul;42(3):189-96. Unique Identifier : AIDSLINE

Phosphate and H-phosphonate derivatives of anti-HIV nucleoside analogues (AZT and d4T) were prepared as potential prodrugs of the bio-active free nucleotide and they were evaluated for their inhibitory effects on the replication of HIV-1 in several cell culture systems. One compound exhibited an important anti-HIV-1 activity and proved to be significantly more efficient than the parent nucleoside.

JOURNAL ARTICLE Anti-HIV Agents/CHEMICAL SYNTHESIS/*PHARMACOLOGY Cell Line Drug Screening Human HIV-1/*DRUG EFFECTS/PHYSIOLOGY Phosphoric Acids/PHARMACOLOGY Reverse Transcriptase Inhibitors/CHEMICAL SYNTHESIS/*PHARMACOLOGY Stavudine/*ANALOGS & DERIVATIVES Support, Non-U.S. Gov't Zidovudine/*ANALOGS & DERIVATIVES/PHARMACOLOGY



 




Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.