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Delayed-type hypersensitivity reactions to Onchocerca volvulus antigens in exposed and non-exposed African individuals.




 

Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):103-5. Unique Identifier :

Although considered of critical importance, the mode of helper T-lymphocyte function in Onchocerca volvulus infection is still unclear including the role of the Th1/Th2 dichotomy. We studied the delayed-type hypersensitivity (DTH) reaction, which is the classical Th1 response, to O. volvulus antigens in Africans exposed and not exposed to the infection. DTH reactions were found in a small percentage of patients with generalized onchocerciasis, but in a high percentage of patients with localized onchocerciasis, in putatively immune subjects, and also in non-exposed individuals, which may be due to cross-reactivity with other nematodes. These findings support the notions of (i) prenatal influence of maternal O. volvulus infection preventing development of Th1 responses and/or (ii) suppression of Th1 responses by the infection itself.

JOURNAL ARTICLE Adolescence Adult Animal Antigens, Helminth/*IMMUNOLOGY Child Female Guinea Human Hypersensitivity, Delayed/*IMMUNOLOGY Immunity, Cellular Male Middle Age Onchocerca volvulus/*IMMUNOLOGY Onchocerciasis/*IMMUNOLOGY Th1 Cells/IMMUNOLOGY



 




Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.