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Delayed-type hypersensitivity reactions to Onchocerca volvulus antigens in exposed and non-exposed African individuals.


Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):103-5. Unique Identifier :

Although considered of critical importance, the mode of helper T-lymphocyte function in Onchocerca volvulus infection is still unclear including the role of the Th1/Th2 dichotomy. We studied the delayed-type hypersensitivity (DTH) reaction, which is the classical Th1 response, to O. volvulus antigens in Africans exposed and not exposed to the infection. DTH reactions were found in a small percentage of patients with generalized onchocerciasis, but in a high percentage of patients with localized onchocerciasis, in putatively immune subjects, and also in non-exposed individuals, which may be due to cross-reactivity with other nematodes. These findings support the notions of (i) prenatal influence of maternal O. volvulus infection preventing development of Th1 responses and/or (ii) suppression of Th1 responses by the infection itself.

JOURNAL ARTICLE Adolescence Adult Animal Antigens, Helminth/*IMMUNOLOGY Child Female Guinea Human Hypersensitivity, Delayed/*IMMUNOLOGY Immunity, Cellular Male Middle Age Onchocerca volvulus/*IMMUNOLOGY Onchocerciasis/*IMMUNOLOGY Th1 Cells/IMMUNOLOGY


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