Rev Pneumol Clin. 1999 Jun;55(3):182-6. Unique Identifier : AIDSLINE
We report the observation of AIDS patient with a history of cough,
dyspnea, fever, cachexia and bilateral nodular opacities at the chest
X-ray. Infectious etiologies were initially suspected but the recovery
was not obtained with their treatment. Only lung biopsy established the
precise diagnosis of primary pulmonary Burkitt's-like lymphoma (BBL).
The sole extranodal site of BBL at the lungs is an unusual finding.
Generally, this lymphomatous proliferation is observed at the early
period of the HIV infection. Immunodepression and Epstein-Barr virus
(EBV) infection are the major pathogenic basis for BL as indicated by
the high prevalence of EBV genomes found in malignant cells. The lack of
EBV sequences in a significant proportion of Burkitt's lymphoma or BBL
and AIDS-associated non-Hodgkin malignant lymphoma suggest that
alternative pathogenic mechanisms may be involved. This observation
permit to show the difficulties observed before the multiple and
bilateral opacities whom the etiologies are varied. The prognosis of
AIDS-associated BLL is very severe.
JOURNAL ARTICLE d'un lymphome pulmonaire primitif de type Burkitt-like
au cours du SIDA. Adult Antigens, CD/ANALYSIS Biopsy Burkitt
Lymphoma/PATHOLOGY/*RADIOGRAPHY English Abstract Human
Immunohistochemistry Lung/PATHOLOGY Lung
AIDS-Related/PATHOLOGY/*RADIOGRAPHY Male Radiography, Thoracic
Tomography, X-Ray Computed