Med Care. 1999 Sep;37(9):908-25. Unique Identifier : AIDSLINE
OBJECTIVES: Test the reliability and validity of 5 translations of the
34-item version of the MOS HIV for use in multinational clinical trials.
RESEARCH DESIGN: Investigators in five countries followed a standardized
protocol and recruited HIV+ patients stratified by disease stage:
asymptomatic; symptomatic; and AIDS. During routine clinic visits,
patients completed the MOS HIV and a checklist of HIV-related symptoms.
Clinicians reported patients' demographics, most recent CD4+ count and
disease stage. SUBJECTS: Three hundred and sixty three HIV+ outpatients
attending AIDS clinics in The Netherlands, France, Germany, Italy, and
England. MEASURES: Dutch, French, German, Italian, and UK English
translations of the MOS HIV CD4+ cell count and the SCL-57. RESULTS: All
translations recruited roughly equal proportions of each disease stage,
although the number of patients recruited differed by translation (n:
German = 92, French = 86; Italian = 88; UK English = 72; and Dutch =
25). Internal consistency reliability was similar across translations
and adequate (alpha >.70) for all scales except for Mental Health in the
French sample. Multi-trait analyses supported structural validity of the
MOS HIV scales in each translation. Principal component analysis of
scale scores identified 2 dimensions for all translations except German.
For all translations, scores were significantly correlated with symptom
severity scores but were uncorrelated with CD4+ cell counts.
CONCLUSIONS: In general, the 5 translations of the MOS HIV had similar
psychometric properties to those reported in the validation study for
the original US English version of the MOS HIV. With some revision,
these translations promise to provide useful quality of life data from
HIV+ subjects in clinical trials.
JOURNAL ARTICLE MULTICENTER STUDY Activities of Daily Living Adult
CD4 Lymphocyte Count Disease Progression Europe Factor Analysis,
Statistical Female *Health Status *Health Surveys Human HIV
Infections/*CLASSIFICATION/*PSYCHOLOGY Male Psychometrics *Quality of
Life Questionnaires/*STANDARDS Reproducibility of Results Sensitivity
and Specificity Severity of Illness Index Support, Non-U.S. Gov't
*Translating Treatment Outcome United States