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NLM AIDSLINE

Genetic control of schistosome infections by the SM1 locus of the 5q31-q33 region is linked to differentiation of type 2 helper T lymphocytes.




 

Infect Immun. 1999 Sep;67(9):4689-92. Unique Identifier : AIDSLINE

Human susceptibility to Schistosoma mansoni infections is controlled by the SM1 locus on chromosome 5 in q31-q33. This genetic region encodes cytokines which regulate the development of helper T lymphocytes. In the present work, a clonal analysis of CD4(+) T lymphocytes of homozygous resistant and homozygous susceptible subjects was undertaken to evaluate whether SM1 controls helper T-cell differentiation. Of 121 CD4(+) T-cell clones (TCC) from three susceptible (S) and three resistant (R) subjects, 68 proliferated when stimulated by parasite antigens. Parasite-specific TCC derived from susceptible subjects (33 STCC) produced 10- to 1,000-fold less interleukin-4 and -5 than TCC from resistant subjects (25 RTCC). Clones from both patient groups produced, however, the same amount of gamma interferon. Parasite-specific STCC were type 1 helper (Th1) or Th0/1, whereas RTCC were either Th2 or Th0/2. These results, together with the localization of SM1 in 5q31-q33, indicate that the SM1 locus controls the differentiation of Th2 lymphocytes.

JOURNAL ARTICLE Adolescence Adult Animal Cell Differentiation Child *Chromosomes, Human, Pair 5 Genetic Predisposition to Disease/IMMUNOLOGY Human Immunity, Natural/GENETICS/IMMUNOLOGY Immunophenotyping Interleukin-4/BIOSYNTHESIS Interleukin-5/BIOSYNTHESIS Schistosoma mansoni/IMMUNOLOGY Schistosomiasis mansoni/*GENETICS/IMMUNOLOGY Support, Non-U.S. Gov't Th2 Cells/*IMMUNOLOGY



 




Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.