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Genetic control of schistosome infections by the SM1 locus of the 5q31-q33 region is linked to differentiation of type 2 helper T lymphocytes.


Infect Immun. 1999 Sep;67(9):4689-92. Unique Identifier : AIDSLINE

Human susceptibility to Schistosoma mansoni infections is controlled by the SM1 locus on chromosome 5 in q31-q33. This genetic region encodes cytokines which regulate the development of helper T lymphocytes. In the present work, a clonal analysis of CD4(+) T lymphocytes of homozygous resistant and homozygous susceptible subjects was undertaken to evaluate whether SM1 controls helper T-cell differentiation. Of 121 CD4(+) T-cell clones (TCC) from three susceptible (S) and three resistant (R) subjects, 68 proliferated when stimulated by parasite antigens. Parasite-specific TCC derived from susceptible subjects (33 STCC) produced 10- to 1,000-fold less interleukin-4 and -5 than TCC from resistant subjects (25 RTCC). Clones from both patient groups produced, however, the same amount of gamma interferon. Parasite-specific STCC were type 1 helper (Th1) or Th0/1, whereas RTCC were either Th2 or Th0/2. These results, together with the localization of SM1 in 5q31-q33, indicate that the SM1 locus controls the differentiation of Th2 lymphocytes.

JOURNAL ARTICLE Adolescence Adult Animal Cell Differentiation Child *Chromosomes, Human, Pair 5 Genetic Predisposition to Disease/IMMUNOLOGY Human Immunity, Natural/GENETICS/IMMUNOLOGY Immunophenotyping Interleukin-4/BIOSYNTHESIS Interleukin-5/BIOSYNTHESIS Schistosoma mansoni/IMMUNOLOGY Schistosomiasis mansoni/*GENETICS/IMMUNOLOGY Support, Non-U.S. Gov't Th2 Cells/*IMMUNOLOGY


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