Resource Logo

Absence of thallium-201 brain uptake in progressive multifocal leukoencephalopathy in AIDS patients.


Acta Neurol Scand. 1999 Aug;100(2):102-5. Unique Identifier : AIDSLINE

OBJECTIVE: To evaluate the presence of thallium-201 brain uptake determined by thallium-201 brain SPECT (Tl-201 SPECT) in patients with progressive multifocal leukoencephalopathy (PML) and AIDS. MATERIAL AND METHODS: Six AIDS patients with stereotactic biopsy diagnosis of PML were prospectively evaluated with Tl-201 SPECT, Magnetic Resonance Imaging (MRI), and proton magnetic resonance spectroscopy (1H-MRS). Tl-201 SPECT results were compared with 2 patients with AIDS and biopsy proven primary CNS lymphoma. RESULTS: In all patients with PML, Tl-201 SPECT studies showed lack of uptake while MRI demonstrated subcortical white matter focal brain lesions and 1H-MRS disclosed metabolic abnormalities. Intense thallium uptake (uptake ratios of 3.2 and 5.6) was demonstrated in the 2 patients with primary CNS lymphoma. CONCLUSIONS: The present study shows that PML lesions are not detectable on Tl-201 SPECT while MRI and 1H-MRS demonstrate abnormalities, and intense thallium-201 uptake may be detected in primary CNS lymphoma. These results suggest that Tl-201 SPECT is a method which, combined with other non-invasive techniques such as MRI and 1H-MRS, may help in the diagnostic approach of PML and to differentiate PML from other high proliferative brain lesions characterized by positive thallium uptake.

JOURNAL ARTICLE Adult AIDS Dementia Complex/*RADIONUCLIDE IMAGING AIDS-Related Opportunistic Infections/*RADIONUCLIDE IMAGING Brain/RADIONUCLIDE IMAGING Brain Neoplasms/RADIONUCLIDE IMAGING Diagnosis, Differential Energy Metabolism/PHYSIOLOGY Female Human Leukoencephalopathy, Progressive Multifocal/*RADIONUCLIDE IMAGING Lymphoma, AIDS-Related/RADIONUCLIDE IMAGING Magnetic Resonance Imaging Male Middle Age Neurologic Examination Nuclear Magnetic Resonance Support, Non-U.S. Gov't Thallium Radioisotopes/DIAGNOSTIC USE *Tomography, Emission-Computed, Single-Photon


Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.