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4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.


Bioorg Med Chem Lett. 1999 Jul 19;9(14):2019-24. Unique Identifier :

5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1', and S2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S1' and S2' pockets have provided a number of selected analogs that display high HIV-1 protease inhibitory activity. reserved.

JOURNAL ARTICLE Binding Sites Computer Simulation Drug Design Hydrocarbons, Aromatic/CHEMISTRY Hydrogen-Ion Concentration HIV Protease/CHEMISTRY/*METABOLISM HIV Protease Inhibitors/*CHEMISTRY/*METABOLISM/PHARMACOLOGY Inhibitory Concentration 50 Models, Molecular Molecular Structure Pyrones/*CHEMICAL SYNTHESIS/METABOLISM/*PHARMACOLOGY Software Structure-Activity Relationship Sugar Alcohols/METABOLISM Valine/ANALOGS & DERIVATIVES/METABOLISM


Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.