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Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration.


Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1645-6. Unique Identifier

This investigation is devoted to design of short "switch" oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5'- and/or 3'-terminal positions or one of the pyrimidine heterocyclic bases are developed.

JOURNAL ARTICLE Base Sequence HIV Integrase Inhibitors/CHEMISTRY/*PHARMACOLOGY HIV Long Terminal Repeat HIV-1/*GENETICS Intercalating Agents/*CHEMISTRY Oligonucleotides/*CHEMISTRY Support, Non-U.S. Gov't Virus Integration/*DRUG EFFECTS


Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.