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Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.


Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1221-2. Unique Identifier

Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or poly (dG-dC).poly (dG-dC). Modulation of one or more nuclear (nucleolar) processes of the host cell may be responsible for the synergistic antiviral activity.

JOURNAL ARTICLE Antiviral Agents/*PHARMACOLOGY Human HIV-1/*DRUG EFFECTS Magnesium/*PHARMACOLOGY Microbial Sensitivity Tests Poly A-U/*PHARMACOLOGY Support, Non-U.S. Gov't Vesicular Stomatitis-Indiana Virus/*DRUG EFFECTS


Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.