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HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages [see comments]




 

Nat Med. 1999 Sep;5(9):997-103. Unique Identifier : AIDSLINE

Infection of macrophage lineage cells is a feature of primate lentivirus replication, and several properties of primate lentiviruses seem to have evolved to promote the infection of macrophages. Here we demonstrate that the accessory gene product Nef induces the production of two CC-chemokines, macrophage inflammatory proteins 1alpha and 1beta, by HIV-1-infected macrophages. Adenovirus-mediated expression of Nef in primary macrophages was sufficient for chemokine induction. Supernatants from Nef-expressing macrophages induced both the chemotaxis and activation of resting T lymphocytes, permitting productive HIV-1 infection. These results indicate a role for Nef in lymphocyte recruitment and activation at sites of virus replication.

JOURNAL ARTICLE Adenoviridae/GENETICS Animal Cell Line Cells, Cultured Chemokines/BIOSYNTHESIS/GENETICS *Chemotaxis/DRUG EFFECTS Culture Media, Conditioned Cytokines/BIOSYNTHESIS Encephalitis, Viral/IMMUNOLOGY/VIROLOGY Gene Products, nef/GENETICS/*PHYSIOLOGY Human HIV-1/DRUG EFFECTS/GROWTH & DEVELOPMENT/GENETICS/*PHYSIOLOGY *Lymphocyte Transformation/DRUG EFFECTS Macaca Macrophage Inflammatory Protein-1/BIOSYNTHESIS/GENETICS Macrophages/IMMUNOLOGY/METABOLISM/*VIROLOGY Mutation Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. SIV/DRUG EFFECTS/GROWTH & DEVELOPMENT/PHYSIOLOGY T-Lymphocytes/DRUG EFFECTS/*IMMUNOLOGY/VIROLOGY Virus Replication/DRUG EFFECTS



 




Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.