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Case of the month: March 1999--A 26 year old HIV positive male with dura based masses.


Brain Pathol. 1999 Jul;9(3):609-10. Unique Identifier : AIDSLINE

A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neoplasms with long slender nuclei, consistent with leiomyomas. Both tumors were positive for Epstein Barr virus by in situ hybridization. This case report serves to emphasize the importance of considering soft tissue tumors such as leiomyoma in the differential diagnosis of mass lesions that occur in the central nervous system in AIDS and discusses the role of EBV in tumorigenesis.

JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Actins/METABOLISM Adult Brain Neoplasms/*COMPLICATIONS/METABOLISM/PATHOLOGY/VIROLOGY Case Report Herpesvirus 4, Human/ISOLATION & PURIF Human Immunohistochemistry In Situ Hybridization Leiomyoma/*COMPLICATIONS/METABOLISM/PATHOLOGY/VIROLOGY Magnetic Resonance Imaging Male Meningeal Neoplasms/*COMPLICATIONS/METABOLISM/PATHOLOGY/VIROLOGY


Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.