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NLM AIDSLINE

An alternate pathway for type 1 T cell differentiation.




 

Int Immunol. 1999 Aug;11(8):1185-94. Unique Identifier : AIDSLINE

IFN-regulatory factor-1 (IRF-1) gene-disrupted mice are defective in IL-12 and IL-18 gene expression at the transcriptional and post-translational level respectively. The mutant mouse mounts a type 2 T cell response upon bacterial infection because of the impaired induction of the IL-12 p40 gene and IFN-gamma-producing type 1 T cells are not induced. We showed here, however, that different pathogens activate a novel pathway for inducing IFN-gamma-producing type 1 T cells even in an IRF-1-deficient mouse. This pathway is independent of IL-12 and IL-18, and is mediated by a distinct function of macrophage lineage cells. Macrophages of the mutant mice fail to activate the IL-12-dependent pathway, but they function in the IL-12-independent pathway in Plasmodium-infected mice. This leads to the hypothesis that the IL-12-independent novel pathway for inducing IFN-gamma-producing T cells is distinct from the classical type 1/type 2 T cell subset differentiation pathway.

JOURNAL ARTICLE Animal Cell Differentiation DNA-Binding Proteins/GENETICS/*METABOLISM Enzyme-Linked Immunosorbent Assay Gene Expression Regulation Interferon Type II/*BIOSYNTHESIS Interleukin-12/GENETICS/*METABOLISM Interleukin-18/GENETICS/METABOLISM Leishmania major/IMMUNOLOGY Leishmaniasis, Cutaneous/IMMUNOLOGY Listeria Infections/IMMUNOLOGY Macrophages, Peritoneal/*IMMUNOLOGY Malaria/IMMUNOLOGY Mice Mice, Inbred BALB C Mice, Inbred C57BL Phosphoproteins/GENETICS/*METABOLISM Plasmodium berghei Reverse Transcriptase Polymerase Chain Reaction Spleen/CYTOLOGY/IMMUNOLOGY Support, Non-U.S. Gov't Th1 Cells/*CYTOLOGY/*IMMUNOLOGY Transcription, Genetic



 




Information in this article was accurate in December 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.