GMHC Treatment Issues 1993/94 Winter; 7(11/12): 24
Shiitake Mushrooms (Lentinan edodes) are a traditional Oriental herbal
remedy (and currently a popular haute cuisine ingredient) and being
used in the process of making LEM (Lentinan edodes mycelia). LEM is
the active component incubated in water to allow digestion of mycelial
enzymes. The digest of mycelia enzymes is extracted with water,
filtered, sterilized and concentrated into a powder. The LEM powder is
put into ethyl alcohol and freeze-dried to become ethanol-precipitated
LEM or E-P-LEM.
Japanese researchers report that pretreatment of T cell cultures with
.4mg/ml. E-P-LEM protects them from both free-viral and cell-to-cell
HIV infection without cell viability. Pretreatment of HIV with a
.5mg/ml of E-P-LEM made it unable to infect cells at all. The
researchers suggest that E-P-LEM interferes in HIV interaction with
the cellular CD receptor.
These were test tube studies done in Japan, however, and as yet there
are no human trials planned in the US.
1. Tochikura TS, et al. Med. Microb. & Immun., 1988; 177:235-44.
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