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Gay Men's Health Crisis

Protease Drug Interactions


GMHC Treatment Issues 1995 Oct 10; 9(10): 5

The following drug interactions have been reported for the protease inhibitors: Ritonavir (Abbott): Cannot be taken together safely with codeine, Demerol, Darvon, Feldene, Nizoral, Monostat-4, Tranxene, Valium, Versed (anesthesia), Halcion, Zanax, Tambocor, Rythmol, Vascor, Hismanol, Seldane, Tagamet, Paxil, Clozaril. Also: the dosage of clarithromycin should be reduced when taken concurrently with ritonavir.

Indinavir (Merck): elevates blood levels of rifabutin, so the dose of rifabutin must be halved when administered with indinavir.


Copyright © 1995 -Gay Men's Health Crisis, Publisher. All rights reserved to Gay Men's Health Crisis (GMHC) Treatment Issues. Reproduced with permission. Treatment Issues is published twelve times yearly by GMHC, INC. Noncommercial reproduction is encouraged. Subscription lists are kept confidential. GMHC Treatment Issues, The Tisch Building, 119 West 24th Street, New York, NY 10011 Email GMHC. Visit GMHC

Information in this article was accurate in October 10, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.