Being Alive 1992 Mar 5: 8
Fluconazole was approved by the FDA a couple of years ago and has been
used as maintenance therapy for cryptococcal meningitis. For the
initial treatment of this opportunistic infection, physicians have
used Amphotericin B, a toxic drug that many find difficult to take.
Now researchers are asking whether oral fluconazole can be used as
initial treatment. Can crypto be treated without the use of IV
Amphotericin B? A report in a recent New England Journal of Medicine
says that fluconazole may be a reasonable alternative for initial
treatment in patients who are not critically ill.