-- Immune recovery in pediatric HIV patients primarily involves naïve, infection-resistant lymphocytes.
In a study from the United States, the "associations between human immunodeficiency virus type 1 (HIV-1) intracellular DNA and immunological markers were analyzed longitudinally for children with sustained, undetectable RNA levels while receiving highly active antiretroviral therapy (HAART) for 12 years.
"When DNA levels reached a plateau at week 104 of therapy, in contrast to findings for adults, there was no correlation between the CD4+:CD8+ ratio and DNA levels (r=-0.02, p=0.95), and naïve CD4+CD45RA+ lymphocytes predominated," according to A. Saitoh and coauthors at the University of California-San Diego.
"These data suggest that the increased proportion of naïve lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults," the researchers concluded.
Saitoh and colleagues published their study in the Journal of Infectious Diseases (Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children. J Infect Dis. 2004 Apr 1;189(7):1216-20.
Additional information can be obtained by contacting S.A. Spector, University of California-San Diego, Department of Pediatrics, Division of Infection Diseases, Stein Clinical Research Bldg., Room 428, 9500 Gilman Dr., La Jolla, CA 92093 USA.
The publisher of the Journal of Infectious Diseases can be contacted at: University of Chicago Press, 1427 E. 60th St., Chicago, IL 60637-2954 USA.
The information in this article comes under the major subject areas of AIDS & HIV, Immunology, Pediatrics and Virology.
This article was prepared by AIDS Weekly editors from staff and other reports.
Saitoh A, Powell CA, Fenton T, et al., "Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children", J Infect Dis. 2004 Apr 1;189(7):1216-20
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