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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

CHINA: Chinese Researchers Eye Anti-AIDS Gel


Agence France Presse (04.23.12) - Tuesday, April 24, 2012

A Chinese team said Monday that test results assessing the potency of a molecule to block HIV from entering human cells are "encouraging." University of Hong Kong (UKH), Nanjing University, and City University of Hong Kong researchers, working with Shanghai Targetdrug Co., said the TD-0680 molecule could be developed for a microbicide to "prevent HIV sexual transmission" - the cause of more than 90 percent of HIV infections in China.

Such a gel would give people, particularly women, an "alternative method to protect themselves from the virus, in addition to condoms," said Zhiwei Chen, director of the AIDS Institute of UKH's Li Ka Shing Faculty of Medicine. "The ideal solution is to develop an effective vaccine. Since such a vaccine remains elusive, we must explore other strategies such as topical microbicide," he said.

According to the team, TD-0680 is several times more potent than maraviroc, an antiviral developed by Pfizer and approved by the US Food and Drug Administration for clinical treatment.

The study, "CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency Against HIV-1 Entry, Cell-Mediated Infection and a Resistant Variant," was published online in the Journal of Biological Chemistry (2012;doi:10.1074/jbc.M112.354084).


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Information in this article was accurate in April 24, 2012. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.