Treatment Review No. 14; November 1994
New reports have shown that candida infections can become
resistant to fluconazole. Resistance means an infection no
longer responds to treatment. Fluconazole is used for treatment
and prevention of thrush, vaginal candidiasis and other
infections caused by C. albicans.
Resistance to other azole drugs used for treatment have also
been shown. The drugs are ketoconazole, clotrimazole, and
Although these findings require further study, they suggest
that chronic fluconazole therapy in HIV+ patients may be
limited by the development of resistance to the drugs. Chronic
use of a drug means it is used for a long time to suppress and
prevent the disease. People who have become resistant to
fluconazole may have to be treated with amphotericin B.
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