Treatment Review #15; December 1994
Insulin-like growth factor (IGF-1) is produced by the liver
in response to human growth hormone. Many of growth hormone's
effects may be the result of IGF-1. Human growth hormone is
described in the article on serostim on page 3. A trial
comparing growth hormone and IGF-1 for the treatment of
children and adolescents with HIV infection is being
conducted at the National Cancer Institute. To participate in
this trial, you must be 6 to 18 years old with a failure to
grow or less than normal weight or height. Participants will
be divided into two groups. One group will be given IGF-1
twice a day. The second group will be given human growth
hormone once a day. Both treatments are given by shot.
Participants being given IGF-1 will have to be in the
hospital for five days. Total time on study is 6 months.