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Novel Cardiac Biomarker Predicts Progression of Heart Failure in Chronic HIV-Infected Patients


AHA Scientific Sessions 2012

SAN DIEGO--(BUSINESS WIRE)--Critical Diagnostics, makers of the Presage® ST2 Assay, announced today that during a presentation at the American Heart Association Scientific Sessions in Los Angeles, the results of a study demonstrated that elevated levels of the biomarker ST2 in HIV patients was strongly indicative of the development of heart failure and mortality.

The Joint United Nations Program UNAIDS estimates that there are now 33 million people living with HIV/AIDS worldwide. The Center for Disease Control estimates that more than one million people in the U.S. are living with HIV. AIDS ranks with malaria and tuberculosis as one of the top three deadliest infectious diseases among adults, and is the fourth leading cause of death worldwide.

This comprehensive, 8-year retrospective study conducted by researchers at University of California and Massachusetts General Hospital, entitled, ST2 and NT-proBNP Are Associated with Cardiac Dysfunction and Mortality in HIV-Infected Individuals, recruited 332 HIV-infected patients and 50 control subjects asymptomatic for heart failure.

The study concluded that patients with ST2 levels above a specific cut-point had a 40% greater risk of developing diastolic dysfunction. Diastolic dysfunction or diastolic heart failure, which often produces no advanced symptoms at all, refers to decline in performance of one or both ventricles of the heart, where they become stiff, and as a result, cannot fill completely and blood can pool in the body's organs, mainly the lungs.

Furthermore, study results showed that elevated ST2 levels in these HIV-infected patients were modestly associated with risk for systolic dysfunction. Systolic dysfunction is the difficulty of the left ventricle to empty or eject the blood from its chamber and defined in terms of left ventricular ejection.

The natriuretic peptide NT-proBNP was included in the study, but researchers found that while levels were significantly elevated in HIV-infected patients, high concentrations of NT-proBNP were not associated with development of either diastolic or systolic dysfunction. The study did, however, find that a combined elevation of ST2 and NT-proBNP were predictive of death in this patient population.

“Patients with chronic syndromes are known to be at an increased risk for developing heart failure. Unfortunately, identification of which patients are likely to develop diastolic dysfunction is particularly difficult,” notes Critical Diagnostics’ President James Snider. “This study shows that ST2 uniquely predicts which patients with chronic HIV infection are progressing down this path and thus may allow the physician to personalize their treatment.”

“Particularly noteworthy is that ST2 remains not only powerfully prognostic for outcomes in patients with heart failure but this study and similar studies in community cohorts also illustrates the power of ST2 to identify patients who are developing heart failure,” says David Geliebter, CEO of Critical Diagnostics. “This fits perfectly with our goal of helping physicians realize the vision of patient centric medicine.”

About ST2

Soluble ST2 has now been published in more than 50 peer-reviewed articles studying more than 31,000 patients. These clinical studies have demonstrated that high levels of soluble ST2 are predictive of adverse patient outcomes and death in a broad spectrum of cardiovascular disease. They have further shown that the prognostic information from soluble ST2 is independent of, and provides added information to, that of cardiac biomarkers commonly used today, including the natriuretic peptides BNP and NT-proBNP.

About Critical Diagnostics

Critical Diagnostics ( develops novel biomarkers to help physicians optimize patient care in cardiovascular diseases, while containing healthcare costs. The Presage ST2 Assay has been CE Marked and cleared by the US FDA for use in risk stratification with chronic heart failure patients. Critical Diagnostics has exclusive worldwide rights to ST2 for the diagnosis and prognosis of cardiovascular disease.


Critical Diagnostics
Dennis Dalangin, VP Marketing
Telephone: (877) 700-1250


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Information in this article was accurate in November 8, 2012. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.