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Findings from Johns Hopkins University Advance Knowledge in AIDS/HIV Research




 



2012 NOV 12 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- A new study on AIDS/HIV Research is now available. According to news reporting originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "Assays to determine cross-sectional HIV incidence misclassify some individuals with nonrecent HIV infection as recently infected, overestimating HIV incidence. We analyzed factors associated with false-recent misclassification in five African countries."

Our news editors obtained a quote from the research from Johns Hopkins University, "Samples from 2197 adults from Botswana, Kenya, South Africa, Tanzania, and Uganda who were HIV infected > 12 months were tested using the (1) BED capture enzyme immunoassay (BED), (2) avidity assay, (3) BED and avidity assays with higher assay cutoffs (BED + avidity screen), and (4) multiassay algorithm (MAA) that includes the BED + avidity screen, CD4 cell count, and HIV viral load. Logistic regression identified factors associated with misclassification. False-recent misclassification rates and 95% confidence intervals were BED alone: 7.6% (6.6, 8.8); avidity assay alone: 3.5% (2.7, 4.3); BED + avidity screen: 2.2% (1.7, 2.9); and MAA: 1.2% (0.8, 1.8). The misclassification rate for the MAA was significantly lower than the rates for the other three methods (each p< 0.05). Misclassification rates were lower when the analysis was limited to subtype C-endemic countries, with the lowest rate obtained for the MAA [0.8% (0.2, 1.9)]. Factors associated with misclassification were for BED alone: country of origin, antiretroviral treatment (ART), viral load, and CD4 cell count; for avidity assay alone: country of origin; for BED + avidity screen: country of origin and ART. No factors were associated with misclassification using the MAA. In a multivariate model, these associations remained significant with one exception: the association of ART with misclassification was completely attenuated. A MAA that included CD4 cell count and viral load had lower false-recent misclassification than the BED or avidity assays (alone or in combination)."

According to the news editors, the research concluded: "Studies are underway to compare the sensitivity of these methods for detection of recent HIV infection."

For more information on this research see: Specificity of Four Laboratory Approaches for Cross-Sectional HIV Incidence Determination: Analysis of Samples from Adults with Known Nonrecent HIV Infection from Five African Countries. Aids Research and Human Retroviruses, 2012;28(10):1177-1183. Aids Research and Human Retroviruses can be contacted at: Mary Ann Liebert Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Aids Research and Human Retroviruses - www.liebertpub.com/overview/aids-research-and-human-retroviruses/2/)

The news editors report that additional information may be obtained by contacting O. Laeyendecker, Johns Hopkins University, Sch Med, Dept. of Pathol, Baltimore, MD 21205, United States (see also AIDS/HIV Research).

Keywords for this news article include: Maryland, HIV/AIDS, Baltimore, Viral Load, RNA Viruses, Retroviridae, United States, HIV Infections, AIDS/HIV Research, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Microbiological Techniques, Virus Physiological Phenomena, Viral Sexually Transmitted Diseases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2012, NewsRx LLC



 


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Information in this article was accurate in November 12, 2012. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.