2013 JAN 7 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on AIDS/HIV Research. According to news reporting originating from Bucharest, Romania, by NewsRx correspondents, research stated, "Tuberculous meningitis (TBM) has a substantial mortality even with anti-tuberculous treatment, in HIV-non-infected patients. Purpose of the study."
Our news editors obtained a quote from the research from the National Institute of Infectious Disease, "The objectives were to describe clinical and laboratory differences of TBM in HIV-infected versus HIV non-infected patients and to assess risk factors of death in HIV-infected patients. We retrospectively analyzed patients admitted to four infectious diseases hospitals in Romania, between 2001 and 2011, with TBM. Patients were defined as having TBM according to a consensus definition published by Marais et al.  and further divided into three categories of TBM (definite, probable and possible). We identified 162 patients with TBM of which 47 (29%) tested positive for HIV infection. Sixty-six patients had definite, 53 probable and 43 possible TBM. Out of the 47 HIV-infected patients 25 had definite, 17 probable and 5 possible TBM. TBM in HIV-infected patients vs. HIV non-infected patients was significantly associated in multivariable analysis with younger age (p=0.01), in-hospital mortality (p <0.001), absence of meningean syndrome (p=0.021), and absence of cranial nerve palsy (p=0.036). HIV-infected patients who died had a median CD4 count of 61 cells/mm(3) (IQR 21-132) vs. 135 cells/mm(3) (IQR 61-255) in patients who survived (p=0.014). HIV infection was diagnosed before TBM episode in 35 (75%) patients. Twenty-four (51%) HIV-infected patients had concomitant extra-central nervous system tuberculosis. HIV infection is associated with increased mortality in patients with TBM. Most of our patients with TBM were late presenters."
According to the news editors, the research concluded: "Death in HIV infected patients was associated with a lower median CD4 count."
For more information on this research see: Characteristics of tuberculous meningitis in HIV-infected patients. Journal of the International Aids Society, 2012;15(6):18413. (BioMed Central - www.biomedcentral.com/; Journal of the International Aids Society - www.jiasociety.org)
The news editors report that additional information may be obtained by contacting A. Hristea, National Institute of Infectious Diseases 'Prof Dr Matei Bals', Bucharest, Romania (see also AIDS/HIV Research).
Keywords for this news article include: Europe, Romania, HIV/AIDS, Bucharest, Meningitis, RNA Viruses, Retroviridae, Tuberculosis, HIV Infections, AIDS/HIV Research, Vertebrate Viruses, Primate Lentiviruses, Opportunistic Infections, Central Nervous System Diseases, Central Nervous System Infections, Viral Sexually Transmitted Diseases.
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