2013 JUN 3 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Data detailed on Immune System Diseases and Conditions have been presented. According to news reporting from Bethesda, Maryland, by NewsRx journalists, research stated, "We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a."
The news correspondents obtained a quote from the research from the National Institute of Allergy and Infectious Diseases (NIAID), "A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r=-0.7; p<.05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r(2)=0.87, p=.003)."
According to the news reporters, the research concluded: "This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection."
For more information on this research see: Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon Alfa-2a. The Journal of Infectious Diseases, 2012;205(9):1443-7 (see also Immune System Diseases and Conditions).
Our news journalists report that additional information may be obtained by contacting J.J. Hubbard, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States.
Keywords for this news article include: Bethesda, Maryland, Genetics, HIV/AIDS, Treatment, RNA Viruses, Retroviridae, United States, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Human Immunodeficiency Virus, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.
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