Corticosteroid injections can lead to dysfunctions in cortisol levels in people taking HIV protease inhibitors, according to research published in the online edition of the Journal of Acquired Immune Deficiency Syndromes. Investigators in the United States found that 11% of their HIV-positive patients developed hypothalamic-pituitary-adrenal (HPA) axis dysfunction after treatment with local corticosteroid injections. All were taking antiretroviral therapy based on a protease inhibitor (PI). The authors believe that a drug interaction was the reason.
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