2013 JUN 24 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on Immune System Diseases and Conditions. According to news originating from New Delhi, India, by NewsRx correspondents, research stated, "Antibodies against VAR2CSA, the Plasmodium falciparum variant surface antigen that binds placental chondroitin sulfate A, have been suggested to mediate protection against malaria in pregnancy but also to be markers of infection. Here, we aimed to identify clinically relevant antibody responses, taking into consideration variations in parasite exposure and human immunodeficiency virus type 1 (HIV) infection status."
Our news journalists obtained a quote from the research from International Center for Genetic Engineering and Biotechnology, "Levels of immunoglobulin G (IgG) against placental and pediatric isolates, VAR2CSA (DBL2X, DBL3X, DBL5 epsilon, and DBL6 epsilon domains), and other blood-stage antigens (DBL gamma, DBL alpha, MSP1(19), AMA1, and EBA175) were measured in plasma specimens from 293 pregnant Mozambican women at delivery. Associations between antibody responses, factors influencing malaria exposure, HIV infection status, and pregnancy outcomes were assessed. Maternal antibodies were affected by placental infection, parity, season, and neighborhood of residence. HIV infection modified these associations and attenuated the parity-dependent increase in IgG level. High levels of antibody against AMA1, DBL3X, DBL6 epsilon, placental isolates, and pediatric isolates were associated with increased weight and gestational age of newborns (P < .036) among women with malaria episodes during pregnancy. Antiparasite IgGs in women at delivery are affected by HIV infection, as well as by variations in the exposure to P. falciparum."
According to the news editors, the research concluded: "Heterogeneity of malaria transmission needs to be considered to identify IgGs against VAR2CSA and other parasite antigens associated with improved pregnancy outcomes."
For more information on this research see: Improved Pregnancy Outcomes in Women Exposed to Malaria With High Antibody Levels Against Plasmodium falciparum. Journal of Infectious Diseases, 2013;207(11):1664-1674. Journal of Infectious Diseases can be contacted at: Oxford Univ Press Inc, Journals Dept, 2001 Evans Rd, Cary, NC 27513, USA. (Oxford University Press - www.oup.com/; Journal of Infectious Diseases - jid.oxfordjournals.org)
The news correspondents report that additional information may be obtained from A. Mayor, Int Center Genet Engn & Biotechnol, New Delhi, India (see also Immune System Diseases and Conditions).
Keywords for this news article include: Asia, Antibodies, Antigens, India, HIV/AIDS, New Delhi, Immunology, Pediatrics, RNA Viruses, Retroviridae, Blood Proteins, HIV Infections, Immunoglobulins, Biological Factors, Vertebrate Viruses, Primate Lentiviruses, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions
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