2013 OCT 7 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators discuss new findings in Immune System Diseases and Conditions. According to news reporting out of Trieste, Italy, by NewsRx editors, research stated, "Nuclear bodies (NBs), characterized by the presence of the promyelocytic leukemia (PML) protein, are important components of the nuclear architecture, contributing to genetic and epigenetic control of gene expression. In investigating the mechanisms mediating HIV-1 latency, we determined that silenced but transcriptionally competent HIV-1 proviruses reside in close proximity to PML NBs and that this association inhibits HIV-1 gene expression."
Our news journalists obtained a quote from the research from Molecular Medicine Laboratory, "PML binds to the latent HIV-1 promoter, which coincides with transcriptionally inactive facultative heterochromatic marks, notably H3K9me2, at the viral genome. PML degradation and NB disruption result in strong activation of viral transcription as well as release of G9a, the major methyltransferase responsible for H3K9me2, and loss of facultative heterochromatin marks from the proviral DNA. Additionally, HIV-1 transcriptional activation requires proviral displacement from PML NBs by active nuclear actin polymerization."
According to the news editors, the research concluded: "Thus, nuclear topology and active gene movement mediate HIV-1 transcriptional regulation and have implications for controlling HIV-1 latency and eradication."
For more information on this research see: Proximity to PML nuclear bodies regulates HIV-1 latency in CD4+ T cells. Cell Host & Microbe, 2013;13(6):665-77. (Elsevier - www.elsevier.com; Cell Host & Microbe - www.elsevier.com/wps/product/cws_home/710654)
Our news journalists report that additional information may be obtained by contacting M. Lusic, Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology ICGEB, 34149 Trieste, Italy. Additional authors for this research include B. Marini, H. Ali, B. Lucic, R. Luzzati and M. Giacca (see also Immune System Diseases and Conditions).
Keywords for this news article include: Italy, Europe, Trieste, Genetics, HIV/AIDS, RNA Viruses, Retroviridae, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.
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