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Findings from French National Institute of Health and Medical Research (INSERM) in the Area of HIV/AIDS Described




 



2013 NOV 4 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on Immune System Diseases and Conditions. According to news reporting from Bordeaux, France, by NewsRx journalists, research stated, "Few studies have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe. Study objectives were to explore the impact of LP on AIDS and mortality."

The news correspondents obtained a quote from the research from the French National Institute of Health and Medical Research (INSERM), "Methods and Findings: LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count <350/mm(3) or an AIDS diagnosis within 6 months of HIV diagnosis among persons presenting for care between 1 January 2000 and 30 June 2011. Logistic regression was used to identify factors associated with LP and Poisson regression to explore the impact on AIDS/death. 84,524 individuals from 23 cohorts in 35 countries contributed data; 45,488 were LP (53.8%). LP was highest in heterosexual males (66.1%), Southern European countries (57.0%), and persons originating from Africa (65.1%). LP decreased from 57.3% in 2000 to 51.7% in 2010/2011 (adjusted odds ratio [aOR] 0.96; 95% CI 0.95-0.97). LP decreased over time in both Central and Northern Europe among homosexual men, and male and female heterosexuals, but increased over time for female heterosexuals and male intravenous drug users (IDUs) from Southern Europe and in male and female IDUs from Eastern Europe. 8,187 AIDS/deaths occurred during 327,003 person-years of follow-up. In the first year after HIV diagnosis, LP was associated with over a 13-fold increased incidence of AIDS/death in Southern Europe (adjusted incidence rate ratio [aIRR] 13.02; 95% CI 8.19-20.70) and over a 6-fold increased rate in Eastern Europe (aIRR 6.64; 95% CI 3.55-12.43). LP has decreased over time across Europe, but remains a significant issue in the region in all HIV exposure groups. LP increased in male IDUs and female heterosexuals from Southern Europe and IDUs in Eastern Europe. LP was associated with an increased rate of AIDS/deaths, particularly in the first year after HIV diagnosis, with significant variation across Europe."

According to the news reporters, the research concluded: "Earlier and more widespread testing, timely referrals after testing positive, and improved retention in care strategies are required to further reduce the incidence of LP."

For more information on this research see: Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE). PLos Medicine, 2013;10(9):45-58. PLos Medicine can be contacted at: Public Library Science, 1160 Battery Street, Ste 100, San Francisco, CA 94111, USA. (Public Library of Science - www.plos.org; PLos Medicine - www.plosmedicine.org)

Our news journalists report that additional information may be obtained by contacting A. Mocroft, INSERM, ISPED, Center INSERM Epidemiol Stat U897, Bordeaux, France. Additional authors for this research include J.D. Lundgren, M.L. Sabin, A.D. Monforte, N. Brockmeyer, J. Casabona, A. Castagna, D. Costagliola, F. Dabis, S. De Wit, G. Fatkenheuer, H. Furrer, A.M. Johnson, M.K. Lazanas, C. Leport, S. Moreno, N. Obel, F.A. Post and Reekie (see also Immune System Diseases and Conditions).

Keywords for this news article include: France, Europe, Bordeaux, HIV/AIDS, RNA Viruses, Epidemiology, Retroviridae, HIV Infections, Vertebrate Viruses, Risk and Prevention, Primate Lentiviruses, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions

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Information in this article was accurate in November 4, 2013. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.