2013 DEC 23 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Research findings on Immune System Diseases and Conditions are discussed in a new report. According to news reporting out of Bethesda, Maryland, by NewsRx editors, research stated, "Purpose of reviewThe genetic characterization of HIV-1 breakthrough infections in vaccine and placebo recipients offers new ways to assess vaccine efficacy trials."
Our news journalists obtained a quote from the research from the Henry M. Jackson Foundation for the Advancement of Military Medicine, "Statistical and sequence analysis methods provide opportunities to mine the mechanisms behind the effect of an HIV vaccine.Recent findingsThe release of results from two HIV-1 vaccine efficacy trials, Step/HVTN-502 (HIV Vaccine Trials Network-502) and RV144, led to numerous studies in the last 5 years, including efforts to sequence HIV-1 breakthrough infections and compare viral characteristics between the vaccine and placebo groups. Novel genetic and statistical analysis methods uncovered features that distinguished founder viruses isolated from vaccinees from those isolated from placebo recipients, and identified HIV-1 genetic targets of vaccine-induced immune responses.SummaryStudies of HIV-1 breakthrough infections in vaccine efficacy trials can provide an independent confirmation to correlates of risk studies, as they take advantage of vaccine/placebo comparisons, whereas correlates of risk analyses are limited to vaccine recipients."
According to the news editors, the research concluded: "Through the identification of viral determinants impacted by vaccine-mediated host immune responses, sieve analyses can shed light on potential mechanisms of vaccine protection."
For more information on this research see: Sieve analysis in HIV-1 vaccine efficacy trials. Current Opinion in HIV and AIDS, 2013;8(5):432-436. Current Opinion in HIV and AIDS can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins - www.lww.com; Current Opinion in HIV and AIDS - journals.lww.com/co-hivandaids/pages/default.aspx)
Our news journalists report that additional information may be obtained by contacting P.T. Edlefsen, Henry M Jackson Fdn Adv Military Med, Bethesda, MD, United States. Additional authors for this research include P.B. Gilbert and M. Rolland (see also Immune System Diseases and Conditions).
Keywords for this news article include: Bethesda, Maryland, Genetics, HIV/AIDS, Vaccines, Virology, RNA Viruses, Retroviridae, United States, HIV Infections, Vertebrate Viruses, Biological Products, Primate Lentiviruses, North and Central America, Clinical Trials and Studies, Acquired Immunodeficiency Syndrome, Viral Sexually Transmitted Diseases
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