2013 DEC 30 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Data detailed on Immune System Diseases and Conditions have been presented. According to news reporting from Bethesda, Maryland, by NewsRx journalists, research stated, "Microalbuminuria is a marker for early kidney disease and cardiovascular risk. The purposes of this study were to determine the prevalence of microalbuminuria in an HIV-infected clinic population, to test the predictive value of a single urine albumin/creatinine ratio (ACR) to identify persistent microalbuminuria and to examine covariates of microalbuminuria."
The news correspondents obtained a quote from the research from the National Institute of Allergy and Infectious Diseases (NIAID), "We conducted a prospective cohort study of HIV-infected subjects (n=182) without proteinuria (urine protein/creatinine ratio ?0.5 g/g), elevated serum creatinine, diabetes, or chronic inflammatory conditions. Subjects completed three research visits within 9 months. Microalbuminuria was defined as the geometric mean ACR of 25-355 mg/g for females and 17-250 mg/g for males. The prevalence of microalbuminuria was 14%. The negative predictive value of a single urine ACR determination was 98%, whereas the positive predictive value was only 74%. Microalbuminuria was similar among Black (15%) and non-Black (14%) subjects (p=0.8). Subjects with microalbuminuria were more likely to have hypertension (p=0.02) and metabolic syndrome (p=0.03). While duration of HIV infection and the level of HIV viremia were similar between groups, those with microalbuminuria were more likely to have a CD4 count <200 cells/?l (p=0.0003). In a multivariate logistic regression analysis, the only significant independent predictors of microalbuminuria were low CD4 count (p=0.018) and current ritonavir exposure (p=0.04). The prevalence of microalbuminuria in an HIV-infected clinic population was similar to earlier reports, and was associated with hypertension and impaired immune function."
According to the news reporters, the research concluded: "A single normal ACR determination effectively excludes microalbuminuria, whereas an elevated ACR requires confirmation."
For more information on this research see: Microalbuminuria in HIV disease. American Journal of Nephrology, 2013;37(5):443-51. (Karger - www.karger.com/; American Journal of Nephrology -
Our news journalists report that additional information may be obtained by contacting C. Hadigan, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Dept. of Critical Care Medicine, National Institutes of Health, Bethesda, MD, United States. Additional authors for this research include E. Edwards, A. Rosenberg, J.B. Purdy, E. Fleischman, L. Howard, J.M. Mican, K. Sampath, A. Oyalowo, A. Johnson, A. Adler, C. Rehm, M. Smith, L. Lai and J.B Kopp (see also Immune System Diseases and Conditions).
Keywords for this news article include: Bethesda, Maryland, HIV/AIDS, RNA Viruses, Retroviridae, United States, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.
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