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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

Growth Factor Boosts Cell Counts in AIDS Patients and Bone Marrow"


Granulocyte-macrohage colony-stimulating factor (GM-CSF) can increase the number and in some cases boost the performance of white blood cells in patients with AIDS, say researchers at Harvard Medical School and the University of California. GM-CSF, known as a hematopoietic ("blood cell-forming") hormone, temporarily increased the levels of circulating leucocytes, other white blood cells, and some sub-classes of leukocytes in patients with AIDS. Principal investigator David W. Golde, director of the UCLA General Clinical Research Center, says that even very small doses boost the number of circulating white cells. Another researcher, Jerome E. Groopman, added, "the white counts were regulated in a safe and dose-dependent fashion." Doctors hope that increasing leukocytes in AIDS patients, who have defects in their hematologic functions as well as immunological problems, will help them fight off opportunistic infections. Further studies may investigate whether GM-SCF can decrease the toxicity of AZT when the two drugs are used together.


Copyright © 1988 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in November 2, 1988. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.