from the food and drug administration: new protocol for trimetrexate in"

CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update From the Food and Drug Administration: New Protocol for Trimetrexate in" Nightingale, Stuart L.
October 21, 1988

A new study will enroll AIDS patients with PCP who have not responded to standard treatments (trimethoprim/sulfamethoxazole and parenteral pentamidine) within 14 days or who have failed to respond to one for at least seven days and have developed serious reactions to the other. The patients will take trimetrexate, which under the "Treatment IND" protocol was previously available only to those with serious reactions to both approved drugs. The new study is uncontrolled. The National Institute of Allergy and Infectious Diseases and trimetrexate manufacturer Warner-Lambert Co. are conducting two approved, multicenter studies for patients with the disease who have not responded well to one of the treatments, but have not had serious adverse reactions to the other. Two other studies will compare the new drug with the approved therapies as initial treatments.

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Copyright © 1988 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles. Information in this article was accurate in October 21, 1988. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.