Nature (06/01/89) Vol. 339, No. 6223, P. 385
A poliovirus antigen chimera containing an epitope from the transmembrane
glycoprotein (gp41) of HIV-1 inhibited neutralization of HIV-1 by
antipeptide monoclonal antibodies specific for the gp41 epitope and
significantly reduced the group specific neutralizing activity of
HIV-1-positive human sera in antibody absorption experiments, David J.
Evans and colleagues report. Rabbit antisera raised by sucutaneous
injection of the polio/HIV chimera neutralized a wide range of American
and African HIV-1 isolates and inhibited virus-induced cell fusion. The
researchers report that their studies suggest that Sabin 1 poliovirus/HIV
chimeras could offer an approach to the development of an HIV vaccine.