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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

An Engineered Poliovirus Chimaera Elicits Broadly Reactive HIV-1"


Nature (06/01/89) Vol. 339, No. 6223, P. 385

A poliovirus antigen chimera containing an epitope from the transmembrane glycoprotein (gp41) of HIV-1 inhibited neutralization of HIV-1 by antipeptide monoclonal antibodies specific for the gp41 epitope and significantly reduced the group specific neutralizing activity of HIV-1-positive human sera in antibody absorption experiments, David J. Evans and colleagues report. Rabbit antisera raised by sucutaneous injection of the polio/HIV chimera neutralized a wide range of American and African HIV-1 isolates and inhibited virus-induced cell fusion. The researchers report that their studies suggest that Sabin 1 poliovirus/HIV chimeras could offer an approach to the development of an HIV vaccine.


Copyright © 1989 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in June 1, 1989. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.