New England Journal of Medicine (09/21/89) Vol. 321, No. 12, P.
Eduardo Cortes of the Federal University of Rio de Janiero and David Ho
and Roger Detels of the UCLA School of Public Health previously reported
that bisexual men, rather than IV drug users, may act as the main route
of HIV transmission between the homosexual and heterosexual communities
in Brazil. The researchers also wrote that dual reactivity of serum with
HIV-1 and HIV-2 indicated dual infection in five reported cases. In
response to letters from Espejo and colleagues from Chile and O'Brien and
colleagues from the United States claiming that the dual serologic
reactivity may have been cross-reaction of large envelope glycoproteins,
Cortes and colleagues write that studies already underway to resolve the
issue will assay serum reactivity with genes unique to each type of HIV.
The researchers caution, however, that Brazil has closer links to West
Africa--where HIV-2 infection is endemic--than Chile or the United