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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

SOUTH AFRICA: Diospyrin Inactivates a Drug Target for Tuberculosis in New Way




 

News-Medical.net (01.18.13) Aids Weekly Plus

Professor Tony Maxwell, a researcher at the John Innes Centre, reported that diospyrin, a compound from the South African toothbrush tree, is effective in treating drug-sensitive and drug-resistant TB. Maxwell stated that diospyrin binds to an enzyme known as DNA gyrase and inactivates the enzyme, which is essential for bacteria. Traditional medicine has used the toothbrush tree’s antibiotic properties to treat bronchitis, pleurisy, and STDs. People also use the tree’s twigs as toothbrushes. Most antibiotics come from natural sources like the soil bacteria Streptomyces, but naturally occurring compounds in plants are another potential source for new antibiotics. It may be possible to learn of other cures from the field of ethnobotany, according to Maxwell, which underscores the importance of preserving biodiversity. [Editor's Note: The full report, “The Naphthoquinone Diospyrin is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action,” was published in the Journal of Biological Chemistry and is available at www.jbc.org/cgi/doi/10.1074/jbc.M112.419069].



 


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Information in this article was accurate in January 18, 2013. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.