2013 MAY 13 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Fresh data on Immune System Diseases and Conditions are presented in a new report. According to news reporting originating from Bronx, New York, by NewsRx correspondents, research stated, "Analysis of factors contributing to high affinity antibody-protein interactions provides insight into natural antibody evolution, and guides the design of antibodies with new or enhanced function."
Our news editors obtained a quote from the research from the Albert Einstein College of Medicine, "We previously studied the interaction between antibody D5 and its target, a designed protein based on HIV-1 gp41 known as 5-Helix, as a model system [Da Silva, G. F.; Harrison, J. S.; Lai, J. R., Biochemistry, 2010, 49, 5464-5472]."
According to the news editors, the research concluded: "Antibody D5 represents an interesting case study because it is derived from the VH1-69 germline segment; this germline segment is characterized by a hydrophobic second heavy chain complementarity determining region (HCDR2) that constitutes the major functional paratope in D5 and several antibodies derived from the same progenitor."
For more information on this research see: Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segment. Bmc Biochemistry, 2013;14():9. (BioMed Central - www.biomedcentral.com/; Bmc Biochemistry - www.biomedcentral.com/bmcbiochem/)
The news editors report that additional information may be obtained by contacting A. Stewart, Dept. of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, United States (see also Immune System Diseases and Conditions).
Keywords for this news article include: Antibodies, Bronx, New York, HIV/AIDS, Immunology, RNA Viruses, Retroviridae, United States, Blood Proteins, HIV Infections, Immunoglobulins, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.
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