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Data on HIV/AIDS Reported by Researchers at Kaiser Permanente


2013 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- New research on Immune System Diseases and Conditions is the subject of a report. According to news reporting originating in San Francisco, California, by NewsRx journalists, research stated, "As a consequence of inhibition of the hepatic cytochrome P450 3A4 isozyme, treatment with HIV protease inhibitors can result in significant drug-drug interactions."

The news reporters obtained a quote from the research from Kaiser Permanente, "One noteworthy interaction is between protease inhibitors and inhaled or intranasal corticosteroids. This interaction can result in adrenal insufficiency and iatrogenic Cushing's syndrome (with symptoms such as rapid weight gain, obesity, facial hirsutism and swelling), as well as hypertension, osteoporosis and decreased CD4 cell count."

According to the news reporters, the research concluded: "In this paper, we review and unite pharmacokinetic data, case reports and current research regarding this drug-drug interaction in order to suggest options for the clinical management of HIV-positive patients requiring treatment with protease inhibitors and inhaled or intranasal corticosteroids."

For more information on this research see: Inhaled corticosteroid use in HIV-positive individuals taking protease inhibitors: a review of pharmacokinetics, case reports and clinical management. HIV Medicine, 2013;14(9):519-529. HIV Medicine can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; HIV Medicine -

Our news correspondents report that additional information may be obtained by contacting P. Saberi, Kaiser Permanente, San Francisco, CA, United States. Additional authors for this research include T. Phengrasamy and D.P. Nguyen (see also Immune System Diseases and Conditions).

Keywords for this news article include: Pharmaceuticals, Drugs, Therapy, HIV/AIDS, Protease, Treatment, California, RNA Viruses, Retroviridae, San Francisco, United States, HIV Infections, Corticosteroids, Pharmacokinetics, Vertebrate Viruses, Primate Lentiviruses, Enzymes and Coenzymes, North and Central America, Viral Sexually Transmitted Diseases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC


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Information in this article was accurate in October 14, 2013. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.