2013 DEC 30 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Current study results on Immune System Diseases and Conditions have been published. According to news reporting from London, United Kingdom, by NewsRx journalists, research stated, "The marshmallow plant (Althaea officinalis L.) has been used for centuries in medicine and other applications. Valuable secondary metabolites have previously been identified in Agrobacterium rhizogenes-generated transgenic 'hairy' roots in this species."
The news correspondents obtained a quote from the research from the St. George's University of London, "In the present study, transgenic roots were produced in A. officinalis using A. rhizogenes. In addition to wild-type lines, roots expressing the anti-human immunodeficiency virus microbicide candidate, cyanovirin-N (CV-N), were generated. Wild-type and CV-N root lines were transferred to liquid culture and increased in mass by 49 and 19 % respectively over a 7 day culture period."
According to the news reporters, the research concluded: "In the latter, the concentration of CV-N present in the root tissue was 2.4 mu g/g fresh weight, with an average secretion rate into the growth medium of 0.02 mu g/ml/24 h. A. officinalis transgenic roots may therefore in the future be used not only as a source of therapeutic secondary metabolites, but also as an expression system for the production of recombinant pharmaceuticals."
For more information on this research see: Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N. Transgenic Research, 2013;22(6):1225-1229. Transgenic Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Transgenic Research - www.springerlink.com/content/0962-8819/)
Our news journalists report that additional information may be obtained by contacting P.M.W. Drake, St. George's University London, Mol Immunol Unit, Res Center Infect & Immun, London SW17 0RE, United Kingdom. Additional authors for this research include L.D. Madeira, T.H. Szeto and J.K.C. Ma (see also Immune System Diseases and Conditions).
Keywords for this news article include: Anti-Infectives, London, Europe, Therapy, HIV/AIDS, RNA Viruses, Retroviridae, United Kingdom, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions
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