A roundup of some recent research published in BioMed Central’s open access journals about HIV. Saturday 1st December is World AIDS Day. The first World AIDS Day was held in 1988 to help commemorate those who have died, raise awareness of the disease, and help drive support for people living with HIV.
- People with HIV require more care during surgery
Effective antiviral therapy means that people with HIV are living a more normal lifespan and consequently suffer the same health problems as the rest of the population. However new research finds that patients undergoing surgery who also have HIV are more likely to get nosocomial infections while in hospital, and would benefit from prophylactic antibiotics. AIDS Research and Therapy 2012, 9:36 doi:10.1186/1742-6405-9-36
LRRK2 inhibition may provide respite from HIV-1 associated neurocognitive disorders
HIV-1 invades the central nervous system (CNS) early after infection and, despite combined antiretroviral therapy, HIV-1 associated neurocognitive disorders (HANDs) remain a serious problem. New research suggests that leucine-rich repeat kinase 2 (LRRK2), known to be a key player in microglia inflammation, is involved in HANDs, and that LRRK2 kinase inhibition is able to ‘protect’ microglia cells in the lab. While further research is needed LRRK2 kinase inhibition may prove an effective therapeutic strategy for HANDs. Journal of Neuroinflammation 2012, 9:261 doi:10.1186/1742-2094-9-261 http://www.jneuroinflammation.com/content/9/1/261/abstract.
The secrets of miRNA in HIV-associated dementia
HIV-associated dementia (HAD) is the most common type of dementia type in young adults under 40 years old. miRNA, a class of small, non-coding, regulatory RNAs, are known to be involved in HIV-host interaction. Comparing mRNA and miRNA profiles of the frontal cortex from HIV positive patients with and without dementia, researchers have found that 68 miRNA were differentially expressed in HAD and correlated with mRNA targets involved in neuronal cell maintenance and function. BMC Genomics 2012, 13:677 doi:10.1186/1471-2164-13-677 http://www.biomedcentral.com/1471-2164/13/677/abstract.
“The problem is ours, it is not CRAIDS”
HIV and AIDS are a world problem. A case study looking at how a global program, the World Bank Multi-Country AIDS Program (MAP) and in particular the Community Response to AIDS (CRAIDS), contributed to the sustainability of CBOs in Zambia, finds that a lack of infrastructure and training resulted in a loss of services. Instead the authors propose a set of principles based on the needs, contexts and experiences of the individuals and families within each community, rather than a single model or formula, which are needed to ensure the sustainability of CBO HIV programs. Globalization and Health 2012, 8:40 doi:10.1186/1744-8603-8-40 http://www.globalizationandhealth.com/content/8/1/40/abstract.
If you have any questions regarding these, or any of our articles, please contact me. With over 240 journals we can help find information about a wide range of biological and medical topics.
Dr Hilary Glover
Scientific Press Officer, BioMed Central
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Notes to Editors
BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector. @BioMedCentral
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