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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

AFRICA: Less-Used HIV Treatment for African Children More Effective


Children living with HIV in sub-Saharan Africa can be treated with one of two antiretroviral drugs nevirapine or efavirenz. Most countries use nevirapine because it is less expensive and a pediatric formula is more readily available. Researchers in the United States and Botswana compared the effectiveness of both drugs and found initial treatment with efavirenz had better results. Elizabeth Lowenthal of the Children’s Hospital of Philadelphia and lead author of the study noted that prices for bulk drug purchases are lower after negotiations between health officials and pharmaceutical companies. Robert Gross, the study’s senior author and a University of Pennsylvania professor, stated that more could be done to make the drug financially viable for treating children in resource-limited settings.

The full report, “Association Between Efavirenz-Based Compared With Nevirapine-Based Antiretroviral Regimens and Virological Failure in HIV-Infected Children,” was published in the Journal of the American Medical Association (2013; 309(17):1803–1809).


Copyright © 2013 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in May 2, 2013. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.