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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update
This Protein May Strangle Tumors

January 22, 1990
Business Week (01/22/90) No. 3142, P. 78

Scientists at Repligen Corp. in Cambridge, Mass., have discovered a natural protein made by blood platelets, platelet factor 4, that blocks the formation of new blood vessels and can retard tumor growth. In animal tests, Repligen scientists showed that the protein inhibited tumor growth by preventing the tumors from forming networks of blood vessels necessary for growth and spread. The company plans to test a drug, Endostatin B, made by recombinant techniques from the active site of the protein this summer in AIDS patients with Kaposi's sarcoma. Kaposi's sarcoma is a cancer that involves rapid growth of endothelial cells, which line blood vessels.