CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update Postnatal Transmission of HIV-1 Associated With Breast Abscess
Van de Perre, Philippe et al.
June 13, 1992
Lancet (06/13/92) Vol. 339, No. 8807, P. 1490
HIV-1 can be transmitted from mother to child during breastfeeding more
than one year after the peak of viremia related to recent maternal
infection, write Philippe Van de Perre et al. of the National AIDS
Control Program in Kigali, Rwanda. Previously, Van de Perre et al.
studied 16 Rwandan mothers followed up for a mean of 16.6 months, in whom
HIV-1 seroconversion was diagnosed post partum and nine of their children
became infected within the same 3-month period as the mother's
seroconversion. But further research has found that after a mean
follow-up period of 26.7 months, two new mothers were found to have
seroconverted. Both late seroconversions transpired 24 months post
partum in mothers who had stopped breastfeeding and the children remained
HIV-negative up to the age of 36 months. One child who was uninfected in
the original report contracted HIV infection 18 months after his mother's
seroconversion. At month 28 his mother had no HIV-related signs but she
had a severe breast abscess which required surgical treatment.
Breastfeeding was stopped one week after the appearance of breast
abscess. The fact that HIV-1 acquisition by the child was temporarily
associated with a breast abscesses indicates that ingestion of
inflammatory cells could contribute to postnatal transmission of HIV-1.